The Pharmaceutical Industry in Canada
D R U G
Having to pay physicians for enrolling their sufferers in Clinical Scientific Studies
Probably the most critical player in the interface between this sort of profession and also the pharmaceutical industry (Brody, 2007
Based on research, Pharmaceutical reps
regularly misinform MDs about drug negative effects (Ubelacker, 2013).
as speaker in industry-
and also the
Profession Of Medicine
Funding for Ongoing Medical Education
for that world…
at any given time
Serving the requirements of
is compare unique car features through our medicines for
patients, their own families, our stakeholders, and society generally.
Inspired with a single goal:
We lead to
Focused on increasing the
global rules of
trade between nations
Trade Related Facets of Intellectual
Property Legal rights Agreement (Journeys)
(agreement under WTO) protection for intellectual
property and supply greater predictability and stability in worldwide economic relations.
NAFTA United States Free Trade Agreement
resolve trade disputes between national
industries and/or governments
(Canada, Mexico, & U . s . States)
inside a timely and impartial manner
Protects patented drugs from
violation (copying) by other (generic) drug manufacturers.
In 1960’s, certainly one of significant reasons drug prices in
Canada is high.
Pharmaceutical industry was against compulsory licensing
Patented medicine is protected against compulsory licensing to import for ten years and also to manufacture for many years in the date of filing.
provides the licensee the authority to manufacture,
use, or sell a patented invention prior to the
might be granted
With No CONSENT
from the patent holder.
THERAPEUTIC PRODUCTS DIRECTORATE (TPD)
Controlled safety, quality, and effectiveness of medication.
HEALTH PRODUCTS AND FOOD BRANCH
Manage health-related risks and advantages of health products and food
Federal department responsible to
maintain and improve
R E S E A R C H A N D
D E V E L O P M E N T
Our prime profit is simply an
accounting illusion created
by treating the R&D expenses
and never as
Year 1 2 3 Total
Sales 500 500 500
R&D expenses 100 150 100
Revenue 400 350 400
R&D expenses as operating expenses
R&D expenses as capital expenses
(investment) with 10% interest.
Year 1 2 3 Total
Sales 500 500 500 1500
R&D expenses 100 150 100 350
Interest (loss) 10 16 26
We’re really losing
lots of money!
The CRITICS say…
real after-tax cost
expenditure would vary from
$56 to as little as $37
(Development and research in Ontario, 2011)
…Not to say other made-in-Ontario
incentives for example:
R&D tax credit
Business-Research Institute tax credit
and 11 new
The CRITICS say…
9 cancer, 3 Chronic obstructive pulmonary disease,
1 seizure, 1 Parkinson’s,
1 Attention deficit hyperactivity disorder, 10 others
glaucoma, HRT, diabetes, fever, cancer discomfort
Utilization Of GENE
G Of Medication
Elevated R&D on neglected illnesses rich in social value
Consistent dedication to safety and effectiveness
Effective regulating marketing practices
Hoechst Marion Roussel Study
Eflornithine = ineffective as≠
Eflornithine = African sleeping
Bristol-Myers Squibb and
Vaniqa (eflornithine HCl) =
undesirable hair on your face
Rosuvastatin = Branded
InnoGen Pharmaceutical =
Rustor = Generic
Depends Upon 3 MAJOR FACTORS
1. Development and research
3. PMPRB or Patented Medicine Prices Review
Board–established underneath the
Slight or no improvement
Generic charges 80% of the trademark
*generic companies give free products,
sometimes allow “buy 1 get 2 free” promos (ranitidine), and provides rebate to pharmacies
Today in Ontario, the federal government
decreased the price of generic drugs:
25% of the trademark
*Ontario has got the cheapest price of generic
(Canadian Pharmacy Association, 2013)
THEN (before patent ends)
Comparison of costs for
Different prices between civilized world and developing country.
Cost of brand name = Cost of generic???
Generic drug manufacturers aren’t needed to
repeat the costly studies that brand
name firms have gone through.
drugs for uncommon illnesses
“When profit and health factors enter into conflict
using the profit…. Then profit wins”
(Bolaria, 2009, p.451)
P R I C E S
Degree of therapeutic improvement
NOW (patent ended)
C A N A D I A N P A T E N A C T
Sets the criteria, directs the procedure, and
provides protection for patency.
(Douglas & Jutras, 2008)
(Bolaria & Dickinson, 2009 Douglas & Jutras, 2008) )
(Douglas & Jutras, 2008)
Compulsory licenses are eliminated with 2 EXCEPTIONS:
– generic drug manufacturers can
get the drugs and affect Health Canada for
approval prior to the patent expires.
– manufacture and convey the
drugs to become offered six several weeks prior to the patent expires.
(WTO, 2013 NAFTA, n.d.)
BILL C-91 AFTER SIGNING Journeys & NAFTA Contracts
Regulating patent term altered to twenty years
Stockpiling exception no more permitted.
(Health Canada, 2012)
HPFB and PHARMACEUTICALS RELATIONSHIP
HPFB lacked funds to attempt clinical
and preclinical trials
Pharmaceutical industry grew to become certainly one of
the main funders of HPFB
INFLUENCES ON HPFB
Delegation of presidency authority to Rx&D
– growth and development of first draft of the new policy.
– to be able to continue operations, HPFB turns to PHARMA COMPANIES for FUNDS.
Weakened Direct-to-consumer Advertising
(DTCA) standards of prescription medications
“HPFB and also the Fda (Food and drug administration) implemented USER Charges payable by INDUSTRY. In exchange, the regulatory agencies decided to Accelerate APPROVALS.” – Batt, 2005
Food and drug administration reviewers 1998 survey demonstrated 27 new drugs shouldn’t happen to be approved.
Are You Aware?
An Action to Amend the
Food and medicines Act
Supplying DRUG SAMPLES
Drug reps are selected for his or her appearance and outgoing natures, and therefore are educated to be observant, friendly, and useful.
The priority is when the practice affects the prescribing decisions from the physician and just how it could, therefore, modify the cost and quality of healthcare.
Studies consistently reveal that samples influence prescribing choices.
College of Family Physicians of Canada revealed 70% of accredited programs had pharmaceutical company funding
Physicians possess a duty to handle existing and potential conflicts of great interest.